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Clinical application considerations include the potential for plant antioxidants as adjunctive therapy alongside conventional PDE5 inhibitors

Natural phytochemicals found in herbs, cereals, seeds, and other plants offer a potential alternative, as they possess bioactive compounds with protective or disease-preventing properties ( Statements Author contributions CX and YC conceptualized the manuscript

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Photostability evaluation To test the photostability in buffer and cell culture media, PLGA nanoparticles encapsulating DDA-GSH-AuNCs in water (2 mg/mL) was mixed with water (control), PBS or DMEM that contains 10% FBS (final concentration of PLGA nanoparticles is 0.5 mg/mL and AuNCs 4 g/mL as gold)