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Research has also examined its role in upregulating matrix metalloproteinase (MMP) activity alongside their inhibitors (TIMPs), suggesting a finely balanced role in extracellular matrix remodelling rather than simple collagen deposition

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A ubiquitously expressed Cre-ER driver was chosen to ensure widespread depletion of Gdf11 across the brain, accounting for both neuronal and non-neuronal cellular sources of GDF11