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The Microsomal Ethanol-Oxidizing System (MEOS) and CYP2E1 Chronic heavy alcohol consumption induces the microsomal ethanol-oxidizing system (MEOS), a secondary metabolic pathway driven by the cytochrome P450 2E1 (CYP2E1) enzyme

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[7] Drugs or toxins that have a pharmacological (type A) hepatotoxicity are those that have predictable dose-response curves (higher concentrations cause more liver damage) and well characterized mechanisms of toxicity, such as directly damaging liver tissue or blocking a metabolic process