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Lancet Psychiatry 3, 760773

The metal ion hypothesis of alzheimers disease and the anti-neuroinflammatory effect of metal chelators

The methionine-to-SAM relationship and inferred adenosine bottleneck are used by Second Opinion Physician as clinical reasoning tools

High-performance liquid chromatography (HPLC) and gas chromatography (GC) coupled with various detection techniques, such as ultraviolet-visible (UV-Vis) spectroscopy, fluorescence detection, or mass spectrometry (MS), enable the sensitive and selective analysis of thiols in diverse sample matrices

Hydroxocobalamine (Sigma-Aldrich, Germany), Ethylenediaminetetraacetic acid (EDTA), propylene glycol (PG), polyethylenglycole (PEG 400), sorbitan mono oleate and buffering agents (Citrate, Acetate and Phosphate) were provided by Merck- Schuchardt, Hohenbrunn, Germany