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The ferroptosis inducers such as glutamate, erastin are able to drain GSH and inactivate the enzymatic activity of GPX4 via blocking the import of cystine by the cystine/glutamate antiporter (system X c ) [27, 28] (Fig

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doi: 10.1016/j.jpha.2019.04.003

This multifaceted regulatory crosstalk renders iron homeostasis imbalance a core amplifier of ferroptosis sensitivity in drug-resistant cancer cells

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