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Making the interval longer puts them at serious risk of: Irreversible neurological damage

49 Similar observation from the previous study also identified that skin fibroblasts and keratinocytes secret Hsp90 to regulate their motility to migrate across the wound bed aiding wound contraction and re-epithelialization

Given the decades and thousands of individuals who have been on creatine, if kidney function were an issue, we should see it by now

My recommendation for best results is to clean up your diet, exercise 3 days a week or take daily walks, drink plenty of water, and look into fiber, protein, and electrolyte supplements