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All experimental protocols were approved by the Ethics Committee at the Medical Faculty, University of Zagreb and conformed to the International Directive 2010/63/EU of the European Parliament on the protection of animals used for scientific purposes

Many chronic injuries involve more than one site

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The review underscores the role of irregular activation of the HGF/c-MET signaling route in facilitating communication between CAFs and various immune elements, modifying ECM components, attracting and integrating immunosuppressive cells (MDSCs, TAMs, and Tregs), and controlling PD-L1 protein expression

A behavioral change of special concern is known as wandering