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[PubMed Central ID: PMC9598923]

The MAPK/ERK pathway is the primary driver of neuronal differentiation and gene expression changes

Human studies consistently report that doses up to 6 g are well tolerated, with no adverse effects noted even in older adults

Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: Initial results from the NHLBI Family Heart Study

Finally, it is important to acknowledge the similar protective role that UA is proposed to have in Alzheimers disease, indicating an influence not restricted to the dopaminergic neurodegeneration and synucleinopathy in PD