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Here, we discovered that XIST is downregulated in SGECs during SS and that XIST -knockout in SGECs induces SS-like phenotypes, characterized by decreased AQP5 expression, and increased SSB antigen levels

10.1016/s0006-2952(96)89626-2 130 SuntresZ

Carbonyl cyanide m-chlorophenyl hydrazine renders the inner mitochondrial membrane permeable to H+, leading to membrane potential destabilisation on both sides of the inner mitochondrial membrane, and then, via the Pink1-Parkin pathway, which is specific for membrane potential destabilisation, the mitochondria undergo further membrane potential (MMP) hyperpolarisation, which generates ROS

As mitochondria produce energy, they naturally generate free radicals as a byproduct of metabolism