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In the SURMOUNT-1 trial with 2,539 adults with obesity, participants on the highest tirzepatide dose (15 mg weekly) lost an average of 20.9% of their body weight over 72 weeks

Clinical data from LS patients also highlight marked gliosis as a characteristic finding, potentially resulting from reactive processes secondary to neuronal damage but it could be also a result of an increased propensity of NPCs to differentiate into astrocytes due to LS-causative mutations and mitochondrial dysregulation

While this isnt as accurate as the first two methods, it will place your dives fairly closely and provide a slight safety margin as well

[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Sutherland B.A., Rahman R.M., Appleton I

In contrast, a qualified mobile practitioner in Manchester could offer the exact same service for closer to 35
