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It catalyses the transfer of electrons from GSH to disulfides (Holmgren, 1989), which maintains the intracellular redox homeostasis in the face of oxidative stress (Jung and Thomas, 1996)

The problem is that glutathione levels decline with age, and they drop faster under chronic stress, heavy alcohol use, smoking, and sustained environmental toxin exposure

PLoS ONE 16:e0247841

Subsequently, the folding intermediates of proinsulin were analysed by reversed-phase high-performance liquid chromatography and matrix-assisted laser desorption/ionization (MALDI) with a time-of-flight MS without centrifugation 52,74

USA 95 , 1005010054 (1998)