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This polymorphism is similar to the wild type NQO1*1, results in substitutional messenger RNA splice sites that can result in a deletion of exon 4 and produce a protein deficient in quinone binding site for which enzyme activity differs according to the substrate [ 61 , 62 , 63 ]
A random forest model further identified twenty-six bacterial genera (e.g., Burkholderia , Dyella , Rhodanobacter , Paenibacillus , Pseudomonas ) as potential contributors to reducing the density of R
Therefore, Met utilization may alter the DNA and histones methylation level, influencing the overall abundance of mRNA and proteins, and, consequently, the upcoming phenotype

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