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[DOI] [PMC free article] [PubMed] [Google Scholar] 265.Pinto, M

[DOI] [PubMed] [Google Scholar] 44.Padmini E., Lavanya S., Uthra V

Deuse, T

Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD

Non-anaemic iron deficiency prevalence is even higher [9]