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Dapagliflozin alleviates diabetic kidney disease via hypoxia inducible factor 1alpha/heme oxygenase 1-mediated ferroptosis

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The Nrf2 pathway is a key player in the antioxidant response to ROS accumulation that regulates glutathione peroxidase (GSH), heme oxygenase-1, NADPH oxidase (NOX) and several other critical pathways [80]