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And they had a significant lower mortality when it came to cardiovascular disease, infectious risk and for cancers

The exposures of interest were concentrations of vitamin B12 biomarkers (plasma vitamin B12, MMA, and holoTC), vitamin B12 intake (from foods and/or supplements), intervention with vitamin B12 (any form, duration, or combination with nutrients or drugs), or genetic variants related to B12 metabolism

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In NAD + -depleted states (e.g., aging or advanced disease), SIRT1 activation consumes residual NAD + , impairing NAD + -dependent repair enzymes such as PARPs, and increasing oxidative stress