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The iron-rich milieu induces upregulation of the iron transporter DMT1 through two sequential mechanisms: First, unbound iron activates hypoxia-inducible factor-1 (HIF-1), which directly binds to the DMT1 promoter to enhance its transcription (Ingrassia et al

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Table 2 Comprehensive overview of the molecular mechanisms, genetic determinants, and therapeutic relevance of necroptosis in the pathogenesis and treatment of multiple myeloma

Second, the phase II metabolizing enzyme 2-ME1 levels, HSD17B1, were lower in males than in females

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