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Superoxide-generated peroxynitrite and H 2 O 2 upregulate arginase-2 [27]

A ferroptosis inhibitor reduces carotid artery neointimal plaques and AS in C57BL/6J and ApoE / mice, indicating that suppressing ferroptosis in VSMCs may alleviate proliferative vascular disease (Yan et al., 2023)

Association of a common genetic variant of the IGF-1 gene with event-free survival in patients with HER2-positive breast cancer

Because mitochondria naturally produce free radicals during energy production, antioxidant systems like glutathione play an important role in helping maintain balance

Figure 2 gives an overview of some of the pathophysiological mechanisms implicating the detrimental effects of oxidative stress and inflammation in conditions of diabetes or related metabolic complications