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Nat Rev Mol Cell Biol 5(5):343354 Semenza G (2011) Mechanisms of disease oxygen sensing, homeostasis, and disease (vol 365, pg 537, 2011)
Ligand binding triggers the autocleavage of procaspase-8 into its active form, which initiates downstream caspase activation and the execution of apoptosis
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Babbush KM, Babbush RA, Khachemoune A
It has similar clinical symptoms to Fei Bi and Fei Wei as described in the traditional Chinese medicine (TCM) classic Jingui Yaolue written by Zhang Zhongjing in the Han Dynasty
