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[DOI] [PubMed] [Google Scholar] 103.Jackson-Rosario S., Cowart D., Myers A., Tarrien R., Levine R.L., Scott R.A., Self W.T

The concept that intracellular ascorbate is crucial for protection against oxidant stress is also supported by results of several in vivo studies
In some patients, the immune response leads to viral destruction and downregulation of inflammation, while others generate a severe proinflammatory hypercytokinemia, multisystem inflammation, and shock, with some patients developing respiratory failure requiring mechanical ventilation [52] (Figure 1)

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