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The single IGF-1 partial deficiency is responsible for mitochondrial dysfunction and is restored by IGF-1 replacement therapy

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Passive reabsorption from the distal tubule The drug passively diffuses back into the plasma from the distal tubule

It is also induced during endoplasmic reticulum stress, regulated by the ATF4-CHOP branch of the unfolded protein response, and elicits an apoptotic response 40