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3.2 Necroptosis Previously thought of as an unregulated and uncoordinated form of cell death, necrosis (or necroptosis) has been identified as an alternative, regulated pathway of cell death, primarily dependent on the tumor necrosis factor receptor 1 (TNFR1) and its ligand, TNF

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Microbiol 8 , 207217 (2010)

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It is important to note that curcumin exhibits a biphasic dose-response relationship: lower doses activate protective pathwaysincluding increased total glutathione (GSx) and GST activitywhile higher doses deplete GSH, reduce related metabolites (e.g., taurine, homocysteine), and may induce pro-oxidant effects or cellular toxicity (Scharstuhl et al., 2009)

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