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Treatment of rats with monocrotaline, a pyrrolizidine alkaloid, was also shown to increase the activity of GS to a comparable level as that of GCL (Yan and Huxtable, 1996)

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However, cerebral amyloid angiopathy (CAA) developed at 22 months, followed by microglial and astrocyte activation and cerebral hemorrhage at 29 months (Herzig et al., 2004)

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