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When treated with a vitamin B12-B6-folate combination, patients with mild cognitive impairment and hyperhomocysteinaemia appear to improve their blood-brain barrier function

[28] show that 13 C-GSH administered to mice is rapidly converted to GSSG and accumulated in red blood cells and liver

Refrigerating it to preserve the incidental amount of ascorbic acid would have a net negative effect on many of the other ingredients not meant for long-term cold storage
