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Description
When NNMT is overactive in adipocytes, SAM is depleted reducing the cells capacity for methylation reactions that regulate gene expression, including the epigenetic programs that control energy expenditure

The majority of TNF is secreted by resident macrophages in adipose tissue (176) and affects adipocyte lipolysis through multiple mechanisms

So it both calls in the development of new vasculature and it promotes the growth of that new vasculature

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