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Despite the short plasma half-life, downstream biological effects in tissue persist substantially longer, consistent with a signaling cascade rather than direct dose-response activity

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On the other hand, for the L-NAME retrobulbar applicationinduced retinal ischemia model and BPC 157 therapy in rats, we should emphasize the point that animal studies per se may be cautious regarding their results, although the role of an animal model is indispensable (Vestergaard et al., 2019)

Pharmacological Reports , 2018 This makes it a valuable adjunct or alternative to proton pump inhibitors (PPIs), which suppress acid but do not repair tissue directly

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