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Paclitaxel, a widely used chemotherapeutic agent, increases ATAD3A expression and thereby prevents PINK1-dependent mitophagy, which impairs the degradation of PD-L1 and contributes to therapy resistance
Experimental results showed that metformin effectively lowered total testosterone levels and free androgen index ( Metformin exerts its efficacy by effectively reducing blood glucose levels, mitigating IR, and facilitating improvements in abnormal glucose metabolism markers
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It also plays a significant role in the evolution of many chronic diseases, such as ulcerative colitis, diabetes, atherosclerosis, and arthritis
