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We tested PLC2 with a c-terminal deletion of both the proximal CTD and distal CTD (PLC2-818) and a mutation (PLC2-P819A) predicted to disrupt formation of the helix loop helix conformation of the proximal CTD that is stabilized upon G q binding (Figure 7A)

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Liu C-W, Tsai H-C, Huang C-C, Tsai C-Y, Su Y-B, Lin M-W et al (2018) Effects and mechanisms of caffeine to improve immunological and metabolic abnormalities in diet-induced obese rats

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