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Description
While the theoretical rationale is sound, no clinical trial has tested this specific combination, and the safety profile of triple-pathway activation through separate compounds is unknown
The 2017 classification regrouped the EDS into six groups (A to F) according to underlying genetic and pathogenic mechanisms [1]
Similarly, treatment of these cells with the Met-activating dimeric macrocycles aML5-PEG3, aMD4-PEG11 or aMD5-PEG11 restored cellular proliferation to a similar degree (Supplementary Fig
10.1007/s10549-014-3015-6 49 CristofanilliM.JohnstonS
83 TurgutalpB.BhattaraiP.ErcetinT.LuiseC.ReisR.GurdalE
