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The hepatotoxicity of PZA is dose-dependent, especially at doses above 40 mg/kg, and correlates with its hepatic metabolism, suggesting a direct toxic effect rather than a hypersensitive or immune-mediated mechanism
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Importantly, this approach could exploit the propensity of cancer cells to scavenge fatty acids from their environment 22
In a recent and detailed study, Cheah et al
[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Stein I.S., Gray J.A., Zito K
