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It is a coenzyme, essential in methylation reactions, including the methylation of homocysteine to methionine and the conversion of methylmalonyl-CoA to succinyl-CoA

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Community sources and pharmacy references describe Hospira as the benchmark because of two attributes that the formula itself does not differentiate: supply chain traceability (every vial is traceable from manufacturing through distribution to end user) and regulatory accountability (FDA-registered facilities are subject to inspection and enforcement)