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Importantly, lncRNAs not only regulate the onset and progression of tumors but also serve as potential therapeutic targets and prognostic markers

Met is then converted to S-adenosylmethionine (SAM), which is a crucial methyl group donor for various reactions in the body, including the methylation of DNA [7], RNA, histones, phospholipids, choline, sphingomyelin, acetylcholine, and other neurotransmitters [8]

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This is illustrated with overlaying the structure of UCHL3- 43 with that of UCHL3-ubiqutin (PDB: 1XD3) 31 in which the inhibitor appears to approach the active site Cys95 from the opposite side of the UCHL3 crossover loop compared to the ubiquitin binding site

References 1 AizaraniN.SavianoA.SagarM