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But their concentrations and formulations vary widely

iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics

This lack of standardization, along with a few ingredients commonly used to create a brown pigment that can react poorly to lasers (causing them to scar in place or become black in color) makes permanent makeup removal one of the most complex laser procedures on the market today
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153 MatsushimaM.FujiwaraT.TakahashiE.MinaguchiT.EguchiY.TsujimotoY.et al (1998)