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10.1128/AAC.02574-18 [DOI] [PMC free article] [PubMed] [Google Scholar] Len-Buitimea A, Garza-Crdenas CR, Garza-Cervantes JA, Lerma-Escalera JA, Morones-Ramrez JR

However, it has not been proven to reduce appetite or promote weight loss
2022;34(4):e20210076

Conversely, IGF-1 acts to provide an inhibitory feedback signal on GH secretion in the hypothalamus by stimulating somatostatin production in the pituitary [8991]
Researchers have discovered that when this peptide is isolated and administered in higher concentrations, its benefits extend far beyond the digestive system (Seiwerth et al., 2014)