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The root tissues are mainly carbohydrate and energy metabolism, which involves multiple DAPs, such as: IDHP, ICDHP, PCKA are isocitrate dehydrogenase, pyruvate carboxylase and ketoacid reductoisomerase proteins in the tricarboxylic acid cycle metabolism pathway, respectively, among which isocitrate dehydrogenase (IDH) exists and is up-regulated in multiple metabolic pathways

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Conformational effects of Gly-X-Gly interruptions in the collagen triple helix

Indeed, upregulated BACH1 levels have been reported in post-mortem PD brains as well as in preclinical disease models and further associated with repression of the expression of NRF2 protective genes (Zhou et al., 2018

doi: 10.1016/j.fochx.2023.100910, 186