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10.1210/er.2009-0014 54 GaleJ

European Journal of Nutrition, 51(1), 4755

This method is considered particularly effective for conditions like non-alcoholic fatty liver disease, where intravenous glutathione has been used to support detoxification systems and combat oxidative stress

As mentioned above, P53 can enhance the susceptibility of cell to ferroptosis by inhibiting SLC7A11 and regulating cystine metabolism and GSH synthesis, revealing P53s new role in tumor suppression and offering a basis for developing antitumor strategies targeting ferroptosis.Given P53s key role in regulating SLC7A11 and ferroptosis, restoring its function is a promising therapeutic approach.Adeno - associated viral vectors can reintroduce wild - type P53 into glioma cells to reverse abnormal SLC7A11 expression and increase ferroptosis sensitivity.Additionally, combining P53 activators with SLC7A11 inhibitors may boost therapeutic efficacy