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will b12 injections cause weight gain Does Vitamin Promote Loss? Does B12 Cause Weight Gain?
Description
Over the full week between doses, total exposure is comparable

Animal studies administering 5-Amino-1MQ orally to diet-induced obese mice have shown dose-dependent reductions in body weight (typically 10-30% reduction compared to vehicle-treated obese controls over 4-12 week treatment periods), with the weight loss primarily reflecting fat mass reduction while lean mass is preserved or even increased

Diabetologia 62, 888899 (2019)
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But the knockout arm complicates it

We suppose the change is because the initial doses are enough to keep B12 levels within the desired range
