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Nat Rev Neurol 15(10):565581

Targeted neurotherapeutics face a challenge in penetrating the blood brain barrier (BBB) (Ballabh et al., 2004

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ALA marketed as a food supplement, when not specified, is a racemic solution of both the S and R isomers, while R-ALA, the naturally occurring form of biologically active ALA, is commonly bound to sodium (Na-R-ALA) as sodium salt