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The residues defining the pocket are Gln404(M6), Lys491(M8), Asn494(M8), Tyr495(M8), Gln498(M8), Asn533(M9), Asp537(M9), Glu591(M10), and Met592(M10)

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22,23 They are now particularly used as surrogate end points in clinical trials, 24,25 pharmacological treatment 26,27 of major pathological conditions including cancer 2832 and heart disease
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