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After 28 days the benzyl alcohol preservative is no longer considered reliable, so the safest choice is to discard the vial and open a new one, even if the water still looks clear

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While the injections can indeed improve energy levels in those with a deficiency, it is essential to note that they are unlikely to provide significant benefits for individuals with normal B12 levels

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En cas de carence lgre modre (complment alimentaire oral) : 1 2 semaines : dbut de reconstitution des rserves hpatiques 4 6 semaines : amlioration de la fatigue, de lhumeur, de la concentration 2 3 mois : normalisation des paramtres sanguins (hmoglobine, volume globulaire moyen) En cas de carence svre (injection intramusculaire) : 48 72 heures : augmentation rapide du taux sanguin de B12 5 10 jours : amlioration notable de la fatigue, rticulocytose (augmentation des jeunes globules rouges, signe de reprise de production) 2 4 semaines : attnuation des fourmillements, amlioration des troubles neurologiques lgers 3 6 mois : amlioration des troubles neurologiques plus profonds (selon la dure de la carence) Forme sublinguale : La forme sublinguale (comprim faire fondre sous la langue) permet une absorption directe dans le sang via les muqueuses buccales