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Mar 16 2010;152(6):346-357
Targeted delivery to cartilage is critical for in vivo efficacy of insulin-like growth factor 1 in a rat model of osteoarthritis
Permanently discontinue ALIMTA for severe and life-threatening bullous, blistering or exfoliating skin toxicity
The peptides very short half-life (3 minutes) means it does not accumulate in tissues over time, reducing concerns about long-term bioaccumulation
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