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One final convergence point of these related signaling events, is the initiation of the p38 MAPK and MAPK/ERK1/2 signaling pathways, that causes changes in gene expression and can modify cell metabolism and proliferation (47)

Diarrhoea (defined as three or more loose or watery stools per day) is an uncommon side effect of vitamin B12 supplementation , though it is listed as a rare or uncommon adverse reaction in the official product information for both oral cyanocobalamin and injectable hydroxocobalamin preparations

For the longitudinal clinical study, ASL perfusion MR images were obtained using a pCASL single-shot echo-planar imaging sequence with the following parameters: TE of 11 ms, TR of 4000 ms, FOV of 220 220 mm, voxel size of 2.75 2.75 mm, slice thickness of 6 mm, 18 slices, a labeling duration of 1650 ms, a post labeling delay of 1600 ms, and 40 control-label pairs

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