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Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimers disease

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Hyperglycemia causes PKC activation and subsequent ROS production via NAD(P)H oxidase in cultured aortic smooth muscle cells [14]

A central component in this response is the Ataxia-Telangiectasia mutated (ATM) gene, a serine/threonine kinase, which is activated in response to DNA double strand breaks 44

Rising demand for GLP-1 drugs despite their high price also presents barriers to access