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In addition, TNF, IL-1 and PMA have been shown to upregulate SOD2 gene through a complex intronic enhancer sequence binding involving NFB, CCAAT-enhancer binding protein (C/EBP), Sp-1 and nuclear factor (NF)-1 (218, 247)

The impact of environmental load

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AMBRA1 promotes the interaction between Beclin-1 and Vps34, activating the class III PI3K complex [19]

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