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Bioessays 2017;39

Primary outcomes were serum creatinine and glomerular filtration rate (GFR)

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By slowing gastric emptying and enhancing feelings of fullness, it helps reduce overall caloric intake

Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice