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Neurochemically, evidence shows that dopaminergic and noradrenergic changes are reversible but functionally relevant, which is consistent with the idea of initial benefits sometimes followed by tolerance [43,55,56,57]

Interestingly, a fungus Trichoderma virens GST ( TvGST ) has been observed to provide tolerance toward Cadmium (Cd) stress (Dixit et al., 2011)

Yang H, Xiong W, Jiang J, Jiang R

Posa L, De Gregorio D, Gobbi G, Comai S (2018) Targeting melatonin MT2 receptors: a novel pharmacological avenue for inflammatory and neuropathic pain