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31 Vemurafenib and dabrafenib are inhibitors of the kinase domain in mutant BRAF (a serine-threonine kinase) and are used for treatment of metastatic melanoma with a V600E BRAF mutation
Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB: Meta-analysis of observational studies in epidemiology: a proposal for reporting
These findings indicate that the action of endogenous leptin is intact in mice with DIO despite hyperleptinaemia and resistance to exogenous leptin, thus challenging the view that leptin no longer suppresses food intake and reduces body weight in obesity
A.GomezP.VargasC.De BustosF.Benito-LeonJ.et al
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