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Description
Formation of protein cross-links by singlet oxygen-mediated disulfide oxidation
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10.1038/nature08040 43 LuS
Given these mechanisms, IGF-targeted therapy lends itself as an attractive backbone to novel combination regimens as a strategy to prevent or overcome treatment resistance, and combinations that incorporate IGF-targeted agents with standard cytotoxic agents and/or other targeted therapies have been investigated preclinically in many human cancers (Table 3)
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