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(II) C-Met is modulated through crosstalk with different membrane receptors, including epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER), Integrin, - catenin, cluster of differentiation-44 (CD44), intercellular adhesion molecule-1 (ICAM-1), Plexin B1, VEGF-A, insulin receptor (INSR), FAS, Mucin 1 (MUC1), neuropilin (Nrp)-1 and -2, and focal adhesion kinase (FAK) (Figure 2

The bottom line is that anyone with active cancer or at risk for cancer should be extremely cautious about using a growth-promoting experimental peptide

In recent years, extensive research has been conducted to develop biomaterials capable of modulating these immunological reactions and assisting in the process of cardiac tissue regeneration (Alvarez et al., 2016

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