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With the exception of the firmly established role of ATRA in acute promyelocytic leukemia, no conclusive evidence is available about the potential therapeutic application of addressing micronutrient deficiencies and personalized nutritional interventions

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Shin K, Fogg VC, Margolis B

[Google Scholar] Lopes, J

Cancer treatments significantly elevate OS through multiple mechanisms: chemotherapeutic agents, particularly alkylating agents and platinum compounds, generate excessive ROS directly damaging sperm DNA and membranes (87, 88), while radiation therapy induces both acute and chronic OS states in testicular tissue, leading to prolonged spermatogenic dysfunction (95)

Gibb, Z