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While theres no definite cutoff for when B12 starts to become unsafe, because people often ask, well somewhat arbitrarily say not to take more than 1,000 g per day over the long-term without guidance from a physician

It works through the red blood cells by enabling them to carry oxygen more efficiently

Inability to hit physical benchmarks you once could

[DOI] [PubMed] [Google Scholar] Agmon N

The prescribers obligation when evidence is thin The standard of care for any compound with a limited human evidence base is consistent across these seven: thinner evidence equals heavier documentation
